Deficits in adaptive upper limb control in response to trunk perturbations in Parkinson's disease
Identifieur interne : 002D41 ( Main/Exploration ); précédent : 002D40; suivant : 002D42Deficits in adaptive upper limb control in response to trunk perturbations in Parkinson's disease
Auteurs : E. Tunik [États-Unis] ; H. Poizner [États-Unis] ; S. V. Adamovich [États-Unis] ; M. F. Levin [Canada] ; A. G. Feldman [Canada]Source :
- Experimental brain research [ 0014-4819 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The ability of patients with Parkinson's disease (PD) to compensate for unexpected perturbations remains relatively unexplored. To address this issue PD subjects were required to compensate at the arm for an unexpected mechanical perturbation of the trunk while performing a trunk-assisted reach. Twelve healthy and nine PD subjects (off medication) performed trunk-assisted reaching movements without vision or knowledge of results to a remembered target in the ipsilateral (T1) or contralateral (T2) workspace. On 60% of the trials trunk motion was unrestrained (free condition). On the remaining 40% of randomly selected trials trunk motion was arrested at movement onset (blocked condition). If subjects appropriately changed arm joint angles to compensate for the trunk arrest, there should be spatial and temporal invariance in the hand trajectories and in the endpoint errors across conditions. The control group successfully changed their arm configuration in a context-dependent manner which resulted in invariant hand trajectory profiles across the free and blocked conditions. More so, they initiated these changes rapidly after the trunk perturbation (group mean 70 ms). Some PD subjects were unable to maintain invariant hand paths and movement errors across conditions. Their hand velocity profiles were also more variable relative to those of the healthy subjects in the blocked-trunk trials but not in the free-trunk trials. Furthermore, the latency of compensatory changes in arm joint angles in movements toward T1 was longer in the PD group (group mean 153 ms). Finally, PD subjects' arm and trunk were desynchronized at movement onset, confirming our previous findings and consistent with PD patients' known problems in the sequential or parallel generation of different movement components. The findings that individual PD subjects were unsuccessful or delayed in producing context-dependent responses at the arm to unexpected perturbations of the trunk suggests that the basal ganglia are important nodes in the organization of adaptive behavior.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000927
- to stream PascalFrancis, to step Curation: 000396
- to stream PascalFrancis, to step Checkpoint: 000890
- to stream Main, to step Merge: 003112
- to stream Main, to step Curation: 002D41
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Deficits in adaptive upper limb control in response to trunk perturbations in Parkinson's disease</title>
<author><name sortKey="Tunik, E" sort="Tunik, E" uniqKey="Tunik E" first="E." last="Tunik">E. Tunik</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue</s1>
<s2>Newark, NJ 07102</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Newark, NJ 07102</wicri:noRegion>
<orgName type="university">Université Rutgers</orgName>
<placeName><settlement type="city">New Brunswick (New Jersey)</settlement>
<region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poizner, H" sort="Poizner, H" uniqKey="Poizner H" first="H." last="Poizner">H. Poizner</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue</s1>
<s2>Newark, NJ 07102</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Newark, NJ 07102</wicri:noRegion>
<orgName type="university">Université Rutgers</orgName>
<placeName><settlement type="city">New Brunswick (New Jersey)</settlement>
<region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Adamovich, S V" sort="Adamovich, S V" uniqKey="Adamovich S" first="S. V." last="Adamovich">S. V. Adamovich</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue</s1>
<s2>Newark, NJ 07102</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Newark, NJ 07102</wicri:noRegion>
<orgName type="university">Université Rutgers</orgName>
<placeName><settlement type="city">New Brunswick (New Jersey)</settlement>
<region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levin, M F" sort="Levin, M F" uniqKey="Levin M" first="M. F." last="Levin">M. F. Levin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Interdisciplinary Research in Rehabilitation, Rehabilitation Institute of Montreal</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Rehabilitation, Faculty of Medicine, University of Montreal</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feldman, A G" sort="Feldman, A G" uniqKey="Feldman A" first="A. G." last="Feldman">A. G. Feldman</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Interdisciplinary Research in Rehabilitation, Rehabilitation Institute of Montreal</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neurological Science Research Center, Department of Physiology, Faculty of Medicine, University of Montreal</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0159414</idno>
<date when="2004">2004</date>
<idno type="stanalyst">PASCAL 05-0159414 INIST</idno>
<idno type="RBID">Pascal:05-0159414</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000927</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000396</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000890</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000890</idno>
<idno type="wicri:doubleKey">0014-4819:2004:Tunik E:deficits:in:adaptive</idno>
<idno type="wicri:Area/Main/Merge">003112</idno>
<idno type="wicri:Area/Main/Curation">002D41</idno>
<idno type="wicri:Area/Main/Exploration">002D41</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Deficits in adaptive upper limb control in response to trunk perturbations in Parkinson's disease</title>
<author><name sortKey="Tunik, E" sort="Tunik, E" uniqKey="Tunik E" first="E." last="Tunik">E. Tunik</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue</s1>
<s2>Newark, NJ 07102</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Newark, NJ 07102</wicri:noRegion>
<orgName type="university">Université Rutgers</orgName>
<placeName><settlement type="city">New Brunswick (New Jersey)</settlement>
<region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poizner, H" sort="Poizner, H" uniqKey="Poizner H" first="H." last="Poizner">H. Poizner</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue</s1>
<s2>Newark, NJ 07102</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Newark, NJ 07102</wicri:noRegion>
<orgName type="university">Université Rutgers</orgName>
<placeName><settlement type="city">New Brunswick (New Jersey)</settlement>
<region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Adamovich, S V" sort="Adamovich, S V" uniqKey="Adamovich S" first="S. V." last="Adamovich">S. V. Adamovich</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue</s1>
<s2>Newark, NJ 07102</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Newark, NJ 07102</wicri:noRegion>
<orgName type="university">Université Rutgers</orgName>
<placeName><settlement type="city">New Brunswick (New Jersey)</settlement>
<region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levin, M F" sort="Levin, M F" uniqKey="Levin M" first="M. F." last="Levin">M. F. Levin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Interdisciplinary Research in Rehabilitation, Rehabilitation Institute of Montreal</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Rehabilitation, Faculty of Medicine, University of Montreal</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feldman, A G" sort="Feldman, A G" uniqKey="Feldman A" first="A. G." last="Feldman">A. G. Feldman</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Interdisciplinary Research in Rehabilitation, Rehabilitation Institute of Montreal</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neurological Science Research Center, Department of Physiology, Faculty of Medicine, University of Montreal</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Experimental brain research</title>
<title level="j" type="abbreviated">Exp. brain res.</title>
<idno type="ISSN">0014-4819</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Experimental brain research</title>
<title level="j" type="abbreviated">Exp. brain res.</title>
<idno type="ISSN">0014-4819</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term>
<term>Body movement</term>
<term>Goal directed movement</term>
<term>Hand</term>
<term>Human</term>
<term>Joint</term>
<term>Motor control</term>
<term>Parkinson disease</term>
<term>Perturbation</term>
<term>Sequential</term>
<term>Trajectory</term>
<term>Upper limb</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Membre supérieur</term>
<term>Perturbation</term>
<term>Mouvement orienté</term>
<term>Articulation</term>
<term>Main</term>
<term>Trajectoire</term>
<term>Mouvement corporel</term>
<term>Séquentiel</term>
<term>Parkinson maladie</term>
<term>Noyau gris central</term>
<term>Contrôle moteur</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The ability of patients with Parkinson's disease (PD) to compensate for unexpected perturbations remains relatively unexplored. To address this issue PD subjects were required to compensate at the arm for an unexpected mechanical perturbation of the trunk while performing a trunk-assisted reach. Twelve healthy and nine PD subjects (off medication) performed trunk-assisted reaching movements without vision or knowledge of results to a remembered target in the ipsilateral (T1) or contralateral (T2) workspace. On 60% of the trials trunk motion was unrestrained (free condition). On the remaining 40% of randomly selected trials trunk motion was arrested at movement onset (blocked condition). If subjects appropriately changed arm joint angles to compensate for the trunk arrest, there should be spatial and temporal invariance in the hand trajectories and in the endpoint errors across conditions. The control group successfully changed their arm configuration in a context-dependent manner which resulted in invariant hand trajectory profiles across the free and blocked conditions. More so, they initiated these changes rapidly after the trunk perturbation (group mean 70 ms). Some PD subjects were unable to maintain invariant hand paths and movement errors across conditions. Their hand velocity profiles were also more variable relative to those of the healthy subjects in the blocked-trunk trials but not in the free-trunk trials. Furthermore, the latency of compensatory changes in arm joint angles in movements toward T1 was longer in the PD group (group mean 153 ms). Finally, PD subjects' arm and trunk were desynchronized at movement onset, confirming our previous findings and consistent with PD patients' known problems in the sequential or parallel generation of different movement components. The findings that individual PD subjects were unsuccessful or delayed in producing context-dependent responses at the arm to unexpected perturbations of the trunk suggests that the basal ganglia are important nodes in the organization of adaptive behavior.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>New Jersey</li>
</region>
<settlement><li>New Brunswick (New Jersey)</li>
</settlement>
<orgName><li>Université Rutgers</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="New Jersey"><name sortKey="Tunik, E" sort="Tunik, E" uniqKey="Tunik E" first="E." last="Tunik">E. Tunik</name>
</region>
<name sortKey="Adamovich, S V" sort="Adamovich, S V" uniqKey="Adamovich S" first="S. V." last="Adamovich">S. V. Adamovich</name>
<name sortKey="Poizner, H" sort="Poizner, H" uniqKey="Poizner H" first="H." last="Poizner">H. Poizner</name>
</country>
<country name="Canada"><noRegion><name sortKey="Levin, M F" sort="Levin, M F" uniqKey="Levin M" first="M. F." last="Levin">M. F. Levin</name>
</noRegion>
<name sortKey="Feldman, A G" sort="Feldman, A G" uniqKey="Feldman A" first="A. G." last="Feldman">A. G. Feldman</name>
<name sortKey="Feldman, A G" sort="Feldman, A G" uniqKey="Feldman A" first="A. G." last="Feldman">A. G. Feldman</name>
<name sortKey="Levin, M F" sort="Levin, M F" uniqKey="Levin M" first="M. F." last="Levin">M. F. Levin</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D41 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D41 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:05-0159414 |texte= Deficits in adaptive upper limb control in response to trunk perturbations in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |